Approved treatments for narcolepsy

Narcolepsy treatment usually involves a combination of medications and lifestyle changes to control symptoms and make it easier to go about daily life. Common narcolepsy symptoms include excessive daytime sleepiness (EDS), an overwhelming urge to sleep throughout the day, and cataplexy, a sudden loss of muscle tone. Although there is no cure for narcolepsy, the appropriate treatment regimen, tailored to individual needs, can help ease symptoms and allow people with narcolepsy to safely participate in daily activities.

Dexedrine Spansule

Dexedrine Spansule (dextroamphetamine sulfate) is an oral therapy that’s approved for the treatment of narcolepsy. It’s available as extended-release oral capsules to be taken once or multiple times daily.

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Dextroamphetamine-amphetamine

Dextroamphetamine-amphetamine is an oral therapy that’s approved for the treatment of narcolepsy in people ages 6 and older. It’s available as oral tablets to be taken one to three times daily.

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Lumryz

Lumryz (sodium oxybate) is an oral therapy that’s approved to manage excessive daytime sleepiness or cataplexy in adults and children with narcolepsy, ages 7 and older. It’s available as an oral liquid suspension to be taken once nightly.

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Methylin

Methylin (methylphenidate hydrochloride) is an oral therapy that’s approved for the treatment of narcolepsy. It’s available as an oral solution to be taken two to three times daily.

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Nuvigil

Nuvigil (armodafinil) is an oral therapy that’s approved to improve wakefulness in adults with excessive sleepiness related to narcolepsy. It’s available as oral tablets to be taken once daily in the morning.

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Orzeyful

Orzeyful (oveporexton) is an oral therapy that’s approved to treat adults with type 1 narcolepsy. It’s available as oral tablets to be taken twice daily, taken with or without food.

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Provigil

Provigil (modafinil) is an oral therapy that’s approved to improve wakefulness in adults with excessive sleepiness related to narcolepsy. It’s available as oral tablets to be taken once daily in the morning.

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Ritalin

Ritalin (methylphenidate hydrochloride) is an oral therapy that’s approved for the treatment of narcolepsy. It’s available as oral tablets to be taken two to three times daily.

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Sunosi

Sunosi (solriamfetol) is an oral therapy that’s approved to improve wakefulness in adults with excessive sleepiness related to narcolepsy. It’s available as oral tablets to be taken once daily upon awakening.

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Xyrem

Xyrem (sodium oxybate) is an oral therapy that’s approved to manage excessive daytime sleepiness or cataplexy in adults and children with narcolepsy, ages 7 and older. It’s available as an oral liquid solution to be taken twice nightly.

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Xywav

Xywav (calcium, magnesium, potassium, and sodium oxybates) is an oral therapy that’s approved to manage excessive daytime sleepiness or cataplexy in adults and children with narcolepsy, ages 7 and older. It’s available as an oral liquid solution to be taken twice nightly.

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Wakix

Wakix (pitolisant) is an oral therapy that’s approved to manage excessive daytime sleepiness or cataplexy in adults and children with narcolepsy, ages 6 and older. It’s available as oral tablets to be taken once daily in the morning upon waking.

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